The elegant Palazzo Ducale is accessed through a monumental Vignola-style entrance. The interior was restructured based on the plans drawn up by Giacomo della Porta and Carlo Fontana (sixteenth-seventeenth century) during the era of the Altemps. The Weapons Hall is decorated with eighteenth-century frescoes by an unknown artist and there is a large park in the area behind the palace. The Romanesque cathedral was restructured during the late eighteenth century. Inside, there is a fifteenth-century tavola (Our Lady of the Assumption with angels), as well as a tavola by the Umbrian-Raffaellesca school depicting the Adoration of the Magi. The church of San Famiano is notable. It has a medieval structure with a lovely portico, which was added in the fifteenth century and features four ogival arches. The Redeemer, a work dating to the sixteenth century, is portrayed in the lunette of the entrance. The interior has a nave and three aisles, an elevated presbytery and the remains of fifteenth-century frescoes in the apses. The body of St. Famiano, a Cistercian monk from Cologne who died in Gallese in 1150, is preserved in the crypt.

A small museum ("Marco Scacchi") has been set up in the convent of Santa Chiara. It has paintings and frescoes from the fifteenth-seventeenth centuries, an archaeological section with artefacts from the area, educational panels, posters, plastic and other exhibits on ethnographic, geological and naturalistic subjects.